Background: Ideal sealer should be able to kill the remaining bacteria present on the dentinal walls of root canals along with those present deep inside the dentinal tubules. To achieve this, the sealer should not only kill the bacteria by contact action, but also should be able to diffuse inside the dentinal tubules. This is possible only if the sealer has good flow properties. Hence; the present study was to compare efficacy of root canal sealers to prevent fracture resistance. Materials & methods: A total of 120 extracted mandibular first premolars were included for the study. De-coronation of the specimens was done at the length of 15 mm from the root apex, followed by biomechanical preparation using K files. Afterwards; all the samples were divided into three study groups with 40 specimens in each group as follows: Group A: AH Plus root canal sealers and Gutta-percha points, Group B: MTA Fillapex and Gutta-percha points, and Group C: Control group (unobturated teeth).After completion of obturation according to their respective groups, the access cavity was sealed with temporary cement. Afterwards, embedding of the apical end of the specimens was embedded in acrylic resin upto the depth of 5 mm. All the blocks were placed in universal force testing machine and amount of force required to fracture the root was measured in Newton. Results: In the present study, a total of 120 extracted tooth specimens were analysed. Mean force required to fracture the root among the specimens of group A, Group B and Group C was found to be 242.36 N, 172.35 N and 92.56 N respectively. Conclusion: Within the limitations of the present study, this can be concluded that AH Plus root canal sealers provide comparatively better fracture resistance than MTA Fillapex root canal sealer. Key words: Sealer, Root canal, Endodontic.