The field of Endodontics is constantly changing due to introduction of new techniques and technological advances. Advances in endodontic material sciences contribute significantly to the exponential growth in endodontics. Root canal sealers can be classified according to the chemical composition in zinc oxide-eugenol-based, calcium hydroxide-containing, glass-ionomer-based, epoxy-resin-based and methacrylate-resin-based sealers. Bio-ceramics are amongst the recently introduced materials in endodontics which have changed the face of endodontics. The present review focused on some of the important aspects of root canal sealers. Key words: Root canal, Sealers