Odontogenic cysts are relatively common lesions and accounts to form a major part of total biopsies received by any pathology service. This diverse group of lesions exhibit varying presentations ranging from a small innocuous lesion, which may be detected accidentally or may present as a highly aggressive and destructive lesion that may even transform into a malignancy. Among the latter type most notorious are odontogenic keratocyst (OKC). OKC is the one of the rare odontogenic cysts, which attracts many researchers due to its unique characteristics. The treatment of OKC remains debatable. So many authors have described different modalities. Since OKC exhibits high recurrence rate 5-15% of all odontogenic cysts, the ultimate goal of treatment should be complete, adequate removal of the cyst. Treatment should be based on so many parameters such as extent, age, aggressiveness and size of the lesions. Key words: Odontogenic keratocyst, Treatment