Background: Resilient lining materials are soft polymers with good flexibility and softness properties. The present study was conducted to evaluate the effect of sandblasting and monomer pretreatment of denture base resin on tensile bond strength of two long term resilient liners such as Super-Soft, and Molloplast-B. Materials & Methods: The present in vitro study was conducted on two resilient liners Super-Soft and Molloplast-B. Ninety acrylic resin (Trevalon) specimens with cross sectional area of 12×14 mm were prepared and divided into two groups of 45 specimens each. Each group was surface treated (n = 15) by sandblasting (250 μalumina particles) (Group I), monomer treatment (for 180 sec) (Group II) and control (no surface treatment) (Group III). Tensile strength was determined. Results: mean TBS with super- soft material was 2.5 MPa and with Molloplast-B was 1.6 MPa in group I, 1.4 MPa with super- soft material and 0.98 with Molloplast-B group II, 4.1 MPa and 2.3 MPa with super- soft material and Molloplast-B respectively. The difference was significant (P< 0.05). Conclusion: Authors found that surface pretreatment of the acrylic resin with monomer prior to resilient liner application are an effective method to increase bond strength between the base and soft liner. Key words: Bond strength, Liner, denture base resin