Background: Pulmonary arterial hypertension (PH) is a recently recognized complication of chronic kidney disease (CKD), especially in end-stage renal disease. It is an independent predictor of increased mortality in CKD patients. The aim of this study is to analyze the prevalence of PH in patients in various CKD stages, its severity in different stages of CKD, various related biochemical parameters, and their relation to PH in CKD patients were analyzed. Materials & Methods: Present study was conducted on 50 CKD patients. Every subject was subjected to transthoracic two dimensional echocardiography and pulmonary artery systolic pressure were obtained. Results: The prevalence of PH in CKD patients was 36%. The prevalence of PH increased as CKD stage advanced .Prevalence of PH is also increased in patients on dialysis and AVF group. There was a positive correlation between PH and Hemoglobin and no significant association of calcium and phosphorus in PH group compared to non-PH group. Severity of PH correlate with stages, as stage progress severity of PH increases. Conclusion: The prevalence of PH in CKD patients is 36%. Prevalence of PH had positive correlation with stage of CKD, those on hemodialysis, and those with AVF. The severity of PH was also directly proportional to stages of CKD, as stage progress severity of PH increases. Key words: Pulmonary arterial hypertension, Chronic kidney disease, End-stage renal disease.