Background: Oral cancer (OC) is the leading cause of morbidity and mortality due to cancer in India. The present study was conducted to assess serum lipid profile in patients with oral squamous cell carcinoma (OSCC) patients. Materials & Methods: This study was conducted on 25 OSCC patients of both genders. Equal number of controls was selected. 5ml of blood sample was collected from each patient and stored in vacutainers. Blood was allowed to clot and then centrifuged for 15 min at 3000 rpm to separate the serum for lipid analysis on chemical analyzer. Results: Out of 25 patients, males were 18 and females were 07. The mean cholesterol in OSCC patients was 143.7mg/dl and in control was 180.2 mg/dl, HDL was 37.8 mg/dl in OSCC and 55.6 mg/dl in control, triglycerides was 105.2 mg/dl in OSCC and 148.2 mg/dl in control. LDL was 105.4 mg/dl in OSCC and 140.6 mg/dl in control. VLDL was 24.5 mg/dl in OSCC and 23.5 mg/dl in control. The difference was significant (P< 0.05). Conclusion: Authors found that there was significant reduction in lipid profile in patients with oral squamous cell carcinoma. Key words: Lipid, Triglyceride, SCC