Background: A femoral shaft fracture is usually a high-energy injury and, thus, is likely to be accompanied by an injury of adjacent joints such as a knee ligament injury. Hence; the present study was undertaken for assessing the risk factors of knee fractures. Materials & methods: A total of 100 patients who reported to the department of orthopedics with knee fractures were included in the present study. Complete demographic of all the patients was obtained. Radiographic assessment of all the patients was done. Complete hematological and biochemical profile of all the patients was obtained. All the results were recorded in Microsoft excel sheet and were analyzed by SPSS software. Results: Significant results were obtained while assessing the age-wise distribution of patients. Among 40 females, 23 patients were of postmenopausal status. 69 patients were obese while remaining 31 percent of the patients were non-obese. Osteoporosis was found to be present in 56 percent of the patients. Postmenopausal status and obesity were found to be significant risk factor of knee fractures. Conclusion: Early identification of risk factors (obesity and postmenopausal status) for knee fractures is essential for early detection and prevention.