Background: Oral premalignancy is considered as an intermediate stage. Serum fucose levels are raised in different groups of malignancies including oral cancer. Hence; the present study was undertaken for assessing and comparing Serum Fucose Levels in oral Leukoplakia patients and Oral Cancer Patients. Materials & methods: A total of 25 oral leukoplakia patients and 25 oral cancer patients were included in the present study. Blood samples were obtained from all the patients and were sent to the central laboratory for assessment of serum fucose levels. All the results were recorded in Microsoft excel sheet and were assessed by SPSS software. Chi- square test was used for assessment of level of significance. Results: Mean serum fucose levels among the oral leukoplakia patients was found to be 9.12 mg/dL while mean serum fucose levels among oral cancer patients was found to be 14.12 mg/dL. On comparing, it was observed that mean serum fucose levels of the patients of the oral cancer group was significantly higher in comparison to the patients of the oral leukoplakia group. Conclusion: Alterations in serum fucose levels do occur significantly in oral cancer patients in comparison to oral leukoplakia patients. Key words: Fucose, Oral leukoplakia, Serum