Completely edentulous maxilla and a mandible with only anterior teeth remaining is a common clinical situation seen that causes progressive loss of bone in the posterior aspect of the mandible. If the bilateral distal extension mandible and completely edentulous maxilla are rehabilitated with removable partial dentures, there are chances that the mandibular denture base sinks gradually because of resorption of alveolar bone in the posterior aspect of mandible leading to a posterior open bite. Early loss of bone from the posterior part of the mandible leads to increase in function in the anterior region as a result of posterior hypofunction. The combination syndrome is best managed by prevention. However, if it does occur there are various treatment options that can be considered
Key words: Edentulous, Hypofunction, Syndrome