Introduction:The success of any endodontic treatment is directly associated with infection control ability of the irrigating solution. Available data indicates that any rotary, hand or hybrid instrumentation, even when performed correctly, is unable to remove all organic and inorganic debris from the root canal complex. Therefore, this being the main reasons that irrigating solutions play a chief role in making up for the shortcomings of instrumentation and aiding in endodontic disinfection procedures. Now considering Sodium hypochlorite (NaOCl) solution, is the standard irrigating solution for cleaning and disinfection of the root canal complex. It has active antimicrobial and histolytic characteristics, among other properties.Material and method: A detailed study analysis was designed for the comparison of two main irrigating solutions. The study was conducted in our clinic. An informed consent was obtained from each patient. The study comprised of 130 patients over a period of 6 months. Patients were having chronic apical lesions and were non-vital on the EPT monitor. All patients of age group 18-55 years were included in the study. Exceptions were made in case of immune-compromised patients, patients with history of T.B, history of hepatitis, history of bleeding disorder, calcified and ankylosed teeth and improper apical formation. Only those patients were included who were not in pain. Also, all patients were advised not to take any pain medication one week prior the procedure.Results: The results were obtained manually and later were interpreted electronically. Group A and group B had 75 patients each. Group A had 32 females and group B had 27 females. On the scale of discomfort, group A patients had more post obturation pain i.e. in 18 individuals of score 3 and 4. Group B had merely 09 patients who had a discomfort score of 3 and 4.Conclusion: Both of the irrigating solutions tested in this study (5.25% NaOCl and 2% Chlorhexidine with 0.9% NaCl) were associated with low rates of postoperative pain among patients undergoing single-visit endodontic treatment for chronic apical lesion with pulp necrosis. Keywords:Endodontic, hypochlorite, pain. Received: 13 May 2018 Revised: 16September2018 Accepted: 21September 2018 Corresponding author: Dr Neeraj Sharma, Consultant Endodontist, Noble Dental Clinic and Implant Centre, Kathua, J & K. This article may be cited as:Sharma N, Kaur J, Sharma M.The Role of Various Irrigating Solutions in Endodontic Use: A Clinical Study. Int J Res Health Allied Sci 2018; 4(5):17-19.