Background: Chronic obstructive pulmonary disease (COPD) was previously known as chronic bronchitis and emphysema. The present study was conducted to assess plasma orexin- A level in patients with COPD. Materials & Methods: The present study was conducted in the department of chest & TB on 30 patients with diagnosed cases of COPD. In all patients, 5‑ml blood samples were taken and added into tubes containing EDTA. Orexin‑A level was analyzed via an ELISA method. The body mass index (BMI) was calculated as weight/(height)2 and BMI classifica­tions were determined according to the WHO standards. Results: Out of 30 patients, males were 15 and females were 15. The difference was non- significant (P- 1). Plasma Orexin- A level was 1.4 ng/ml in males and 1.3 ng/ml in females. Th difference was non- significant (P- 0.1). Mean weight in males was 74.2 kg and in females was 70.4 kg, height was 162.8 cm in males and 168.8 cm in females, BMI was 27.2 Kg/m2 in males and 28.4 Kg/m2 in females, BMR was 1526 Kcal in males and 1348 Kcal in females. The difference was significant in relation to height and BMR (P< 0.05). The level was higher in obese males (1.4 ng/ml) and females (1.3 ng/ml). It was lowest in underweight males (0.7 ng/ml) and obese females (0.8 ng/ml). The difference was significant (P< 0.05). Conclusion: Orexin-A may be associated with the severity of hypoxemia in COPD patients. Its level found to be increased in obese patients as compared to underweight patients of COPD.
Key words: Body mass index, Orexin-A, Obese.

Corresponding author: Dr. Lalit Mishra, Associate Professor, Department of Chest and Tb, Career Institute of medical science & Hospital Lucknow, Uttar Pradesh, India

This article may be cited as:  Singh S, Mishra L. Assessment of Plasma Orexin- A level in patients with COPD- A Clinical Study. Int J Res Health Allied Sci 2015;1(1):28-30.