Aim of the study: To assess the role of Mean Platelet Volume and serum uric acid levels as additional markers for the diagnosis of Neonatal Sepsis. Materials and Method: The present hospital based study was carried out in the Neonatal Intensive Care Unit, Teerthanker Mahaveer Hospital, Moradabad to assess the role of Mean Platelet Volume and serum uric acid levels as additional markers for the diagnosis of Neonatal Sepsis. Blood was drawn from the infants, who had clinical signs of sepsis, from peripheral vein under strict aseptic precautions for evaluation of TLC, C-reactive protein (CRP), micro-ESR, MPV and serum uric acid was sent and analysed for case and MPV and URIC ACID was analysed for control group. The software used for the statistical analysis were SPSS (statistical package for social sciences) version 21.0. The statistical test used was Unpaired or Independent t-test for comparison of mean value between 2 groups. Results: The mean Platelet Volume was significantly more among Neo-natal sepsis patients (10.29±1.23) than non-sepsis patients (9.12±1.07).The mean Serum Uric Acid among Neo-natal sepsis patients was 4.01±0.11 and among non-sepsis patients was 3.54±0.55 with no significant difference. Conclusion: MPV is a simple laboratory investigation. In this study we found that neonates with sepsis had higher MPV levels with no difference in the serum uric acid levels.
Key words: C-reactive protein, Mean Platelet Volume, Neonatal Sepsis, Serum Uric Acid.