Objective: This study aimed to compare the clinical outcomes and patient experiences between single-visit and multiple-visit root canal treatments in patients with irreversible pulpitis or apical periodontitis. Methods: A prospective clinical study was conducted with 50 patients requiring root canal treatment, randomly allocated to either single-visit (n=25) or multiple-visit (n=25) treatment groups. Clinical outcomes were assessed based on post-operative pain, periapical healing, and treatment success rates at 1 week, 1 month, and 6 months follow-up. Patient experiences were evaluated using a standardized questionnaire addressing anxiety levels, comfort, satisfaction, and preference. Results: No statistically significant difference was observed in treatment success rates between the groups (92% for single-visit vs. 88% for multiple-visit, p>0.05). Post-operative pain was slightly higher in the single-visit group at 24 hours but equalized at 72 hours. Patient satisfaction scores were significantly higher in the single-visit group (8.7/10 vs. 7.2/10, p<0.05), with time efficiency and reduced appointments being the primary advantages reported. The multiple-visit group showed slightly better outcomes for complex root canal systems and cases with pre-operative symptoms. Conclusions: Both treatment approaches demonstrated comparable clinical success rates, with single-visit treatment showing advantages in patient satisfaction and convenience, while multiple-visit treatment may be preferable for complex cases. The choice between treatment protocols should be determined based on case-specific factors and patient preferences.