Ulceroproliferative growth in the mouth is a symptom of oral squamous cell carcinoma; a type of cancer that can appear as an ulcerative lesion in the oral mucosa. It can occur anywhere from the lips to the oropharynx, but is most common on the gingivobuccal sulcus of the mandible, tongue and floor of mouth. Despite advancements in diagnostics and treatment, oral ulceroproliferative growth poses challenges due to their diverse aetiology, overlapping clinical features, and potential for misdiagnosis. Early identification and timely intervention remain pivotal to improving patient outcomes.