Aim: To assess the levels of C-reactive protein (CRP) in patients with dental implant failure. Materials and methods:The present study aimed to assess C-reactive protein (CRP) levels in patients experiencing dental implant failure. A total of 50 patients scheduled for prosthetic rehabilitation of missing molars were enrolled. Baseline hematological and biochemical parameters were recorded. All dental implant procedures were performed under strict aseptic conditions, and postoperative antibiotic therapy was prescribed for all patients. Radiographic evaluation was conducted after three months to assess prognosis. CRP levels were measured in all patients and compared based on their prognosis. Data analysis was done using SSPS software. Results: A total of 50 patients, comprising 24 males (48%) and 26 females (52%) were included. Regarding age distribution, 20 patients (40%) were under 40 years old, while 30 patients (60%) were above 40 years old. The comparison of C-reactive protein (CRP) levels between successful dental implants and implant failure cases revealed a significant difference. The mean CRP level in patients with successful dental implants was 0.27 ± 0.16 mg/dL, whereas in those with implant failure, it was notably higher at 0.62 ± 0.21 mg/dL. This difference was statistically significant, with a P-value of 0.003. Conclusion: Higher CRP levels were significantly linked to dental implant failure, indicating their potential as a biomarker for implant prognosis. Keywords: Implants, protein, inflammatory