One of the main issues with conventional fixed orthodontic treatment is its long duration, leading the patients to choose alternative therapeutic approaches with compromised results and adverse effects. Propel is an appliance which is designed to apply alveocentesis procedure. The primary outcome of this study is to evaluate the effects of frequent MOPs and increased number of MOPs on the rate of canine retraction and the secondary outcome is to record the pain perception in the patients mouth following the MOP procedure. The study was carried out to compare and evaluate the effect of number and frequency of MOPs on rate of canine retraction as well as pain perception after performing MOPs. The patients were equally divided into two experimental groups, namely, the MOP1 and MOP2 group. Computer-generated random numbers were generated using Microsoft Office Excel 2007 sheet by a person who is not a primary investigator for the study. The patient’s right side was randomly assigned to either the MOP or control groups. The response from the participants were obtained during the first visit after the MOP procedure. Statistical analysis of the present study was done using Statistical Package for the SocialSciences- SPSS version 22. Our study successfully evaluated the rate of tooth movement using MOP by increasing the number and varying the frequency on every 4th,8th and 12th week and as a result the rate of tooth movement increased significantly. Hence, MOPs can be incorporated into routine orthodontic mechanics and at different stages of treatment, facilitating alignment and root movement, stimulating bone remodeling in areas of deficient alveolar bone, and reducing the stress on anchor units. Hence, MOPs offer a practical, minimally invasive, and safe procedure that can be repeated as needed to maximize the biological response to orthodontic forces. Key words: Canine, Osteoperforation