Aim- This study aimed to assess the effectiveness of three different methods for removing the Resilon/New Epiphany self-etch (SE) soft resin endodontic obturation system. Materials and methods- 45 single-rooted extracted teeth were decoronated to a standardized root length and prepared for root canal treatment. Working lengths were established at 1 mm short of the apical foramen, and root canals were instrumented using Mtwo rotary instruments with irrigation protocols including 2.5% NaOCl, 17% EDTA, and saline. Canals were dried with paper points and obturated using Resilon cones and Epiphany SE sealer via cold lateral compaction. The teeth were divided into three groups (n=15). Group 1 underwent retreatment using Mtwo R/Mtwo rotary files. Group 2 employed Endosolv R. Group 3 used the same files with chloroform to soften the filling material. In all groups, smooth canal walls free of visible debris marked the completion of retreatment. Final irrigation included 17% EDTA followed by saline, and canals were dried for SEM analysis.Data analysis was done using SSPS software. Results- The Mtwo R/Mtwo group showed mean cleanliness scores of 8.56 ± 1.12 at the coronal portion, 15.53 ± 4.04 at the middle portion, and 14.76 ± 1.73 at the apical portion, with an overall mean score of 14.48 ± 4.82. For the Mtwo R/Mtwo + Endosolv R group, the mean scores were 4.21 ± 2.84 at the coronal portion, 4.73 ± 2.69 at the middle portion, and 5.92 ± 1.32 at the apical portion, with a total mean score of 4.87 ± 2.91. The Mtwo R/Mtwo + Chloroform group recorded mean scores of 5.98 ± 0.99 at the coronal portion, 6.50 ± 1.12 at the middle portion, and 1.54 ± 0.49 at the apical portion, with an overall mean of 7.93 ± 0.25. Conclusion- All methods left some remnants of filling material and debris on the root canal walls. Nevertheless, the use of Endosolv R in conjunction with rotary files was the most efficient at removing the filling material, with the greatest effectiveness observed in the apical third of the root canals.