Background: This study had been carried out to evaluate the comparison of efficacy of two different root canal sealers for endodontic treatment. Material and methods: This research involved a sample of 50 teeth, which were treated with two distinct types of root canal sealers. The teeth were categorized into two groups according to the sealers applied. Group 1 utilized AH Plus root canal sealer, while Group 2 employed MTA Fillapex root canal sealer. The effectiveness of these two sealers was evaluated, and the results were systematically recorded. Statistical analysis was performed using SPSS software. Results: In this study, Group 1 comprised of 25 teeth treated with AH Plus root canal sealer and Group 2 comprised of 25 teeth treated with MTA Fillapex root canal sealer. The mean fracture force of the teeth of Group 1 was 256.34 N and the mean fracture force for the teeth of Group 2 was 194.27 N. Conclusion: The findings of this study indicate that the fracture resistance of the AH Plus root canal sealer surpasses that of the MTA Fillapex root canal sealer. Keywords: root canal treatment, sealer, efficacy