Brief background: Periodontitis is considered as the result of the interaction between microbial factors and the host's immune response. It is an imbalance within the immune system, and as such, both bacteria and environmental factors play an important role in the development and manifestation of this disease. The primary goal in periodontal treatment is the reduction or suppression of pathogens from periodontal sites. This can be achieved through subgingival debridement using machine-driven or hand instruments. Material & Methods: This conventional periodontal treatment, performed quadrant by quadrant in multiple visits, was re-evaluated in the early 1990s when the full-mouth disinfection concept was introduced. This technique was described by Quirynen in 1995, with the intention of performing the scaling and root planing in one or two visits in a 24-hour range. This was done with the goal of avoiding the possibility of cross-contamination between treated and untreated quadrants. It comprised full-mouth scaling and root planing in less than 24 hours with a strict regime of post-operative chlorhexidine use. Result and Conclusion: Over the years, several modifications to the full-mouth disinfection approach have been suggested.This article describes how a modified full-mouth disinfection approach with adjunctive use of laser therapy in deep periodontal pockets helped to avoid potential recontamination by periodontal pathogens at already treated sites and also enhanced the periodontal health of chronic periodontitis patients.