Background:The present study was conducted for assessing serum c reactive protein levels in peri-implantitis patients.Materials & methods:A total of 20 patients with presence of peri-implantitis and 20 healthy controls were enrolled. Complete demographic and clinical details of all the patients was obtained. All the patients were recalled in the morning and blood samples were obtained. All the samples were sent to laboratory where C reactive protein levels were recorded using an auto-analyzer. All the results were recorded and compared using SPSS software. Results:A total of 20 patients and 20 healthy controls were enrolled. Mean age of the patients of the study group and control group was 40.8 years and 42.9 years respectively. Mean peri-implantitis levels among patients of the study group and control group was 0.899 mg/dl and 0.227 mg/dl. While comparing the results, significant results were obtained. Conclusion:C Reactive protein levels were significantly raised among peri-implantitis patients.