Background: A chronic inflammatory mucocutaneous illness that affects the skin, nails, and oral cavity is called oral lichen planus. In this study, curcumin monotherapy and curcumin in combination with prednisone were tested for the treatment of oral lichen planus patient. Materials & Methods: The present study was conducted on 68 patients diagnosed clinically and histologically as oral lichen planus which were divided randomly into 2 groups of 34 each. In group I patients, Curenext oral gel was prescribed for topical application for 15 minutes, three times a day. In group II patients, a paste of crushed tablet of prednisone and curenext oral gel was prescribed for 15 minutes, three times a day. All patients were recalled after 10 days for 1st follow up and 20 days later for 2nd follow up and reticulation, erosion and pain on VAS were recorded. Results: The mean reticulation score at baseline in group I was 1.82, in group II was 1.80, on 10th day in group I was 1.60 and in group II was 1.14 and on 20th day in group I was 0.86 and in group II was 1.42. The difference was significant (P< 0.05). The mean erosion score at baseline in group I was 2.32, in group II was 2.30, on 10th day in group I was 1.95 and in group II was 1.45 and on 20th day in group I was 0.82 and in group II was 0.10. The difference was significant (P< 0.05). The mean VAS score at baseline in group I was 4.10, in group II was 3.94, on 10th day in group I was 3.24 and in group II was 1.92 and on 20th day in group I was 1.26 and in group II was 0.06. The difference was significant (P< 0.05). Conclusion: Authors found that combination of curcumin and prednisone proved to be effective as compared to curcumin alone in patients of oral lichen planus. Key words: Curcumin, Oral lichen planus, Prednisone