Children with Obstructive Sleep Apnea (OSA) have sleep-disordered breathing (SDR) that interferes with their sleep habits, growth, and development. OSA is characterized by partial or total obstruction of the upper airways (UA) during sleep. The purpose of the current study was to evaluate a Karwetzky activator’s effectiveness in treating juvenile OSA patients. Materials & Methods: Children with Obstructive Sleep Apnea (OSA) have sleep-disordered breathing (SDR) that interferes with their sleep habits, growth, and development. OSA is characterized by partial or total obstruction of the upper airways (UA) during sleep. The purpose of the current study was to evaluate a Karwetzky activator’s effectiveness in treating juvenile OSA patients. Results: Of the 54 patients, 24 were boys and 30 were girls. The average Apnea-hypopnea index was 17.4 events per hour at T0, 4.2 events per hour at T1, 8.1 events per hour at T2, and 8.3 events per hour at T3. At T0, T1, T2, and T3, the apnea index was 8.4, 1.4, 3.2, and 4.6 events/hour, respectively. At T0, T1, T2, and T3, the mean oxygen saturation was 94.2, 93.1, 93.5, and 94.1%, in that order. At T0, T1, T2, and T3, the minimal oxygen saturation percentages were 79.2, 83.4, 79.5, and 80.6, respectively. At T0, T1, T2, and T3, the minimal oxygen saturation percentages were 79.2, 83.4, 79.5, and 80.6, respectively. At T0, T1, T2, and T3, the oxygen desaturation index was 13.2, 5.4, 9.4, and 9.2, respectively. At T0, T1, T2, and T3, the percentage of rapid eye movement sleep was 13.7, 14.2, 14.8, and 15.2, respectively. At T0, T1, T2, and T3, the percentage of sleep in the supine posture was 42.3, 47.5, 39.4, and 45.2, respectively. There was a substantial difference (P<0.05). Conclusion: Authors found that Karwetzky activator is useful in management of mild-to-moderate OSA. Key words: Karwetzky activator, Obstructive Sleep Apnea, Sleep.