Objective- The objective of this study was to assess and compare the efficacy of removing the smear layer and organic debris within the tooth canal using EndoVac, and Endoactivator. Materials and methods- In this research, seventy five single-rooted human teeth that had not undergone prior endodontic treatment and had intact apices were utilized. The selection criteria excluded teeth with extensive restorations, root caries, fractures, immature apex, and root length shorter than 10.5 mm. Verification of the presence of a single canal was conducted through radiographs taken in both mesiodistal and buccolingual directions. Data analysis was performed using SPSS. Results- The Endo Activator exhibited superior results in total cleansing, surpassing the control group treated with saline solution, which showed the least favourable outcomes. Conclusion- Both the EndoVac system and the Endo Activator system exhibited significantly greater efficacy in cleansing root canal walls compared to conventional needle irrigation. Keywords- irrigation, EndoVac, Endo Activator