ABSTRACT: Background: This study was conducted to assess the Etiologic and Clinical Profile and Outcome of Encephalopathy Patients at a tertiary care hospital. Material and methods: This was a retrospective, hospital-based study. Overall, 100 subjects were recruited. 70 subjects were males and 30 subjects were females. Acute or subacute onset of altered mental status (AMS), elevated antithyroid antibodies, a rapid response in mental status with corticosteroids, and the absence of structural, infectious, or other metabolic factors that could explain AMS and its response to steroids were the criteria used to diagnose HE.The following conditions were excluded from the study: (a) illness with an infectious, metabolic, toxic, or vascular etiology; (b) illness with a structural lesion or traumatic brain injury; (c) postoperative encephalopathy; and (d) patients under the age of 18 years. Out of the 100 patients who were examined, 30 had high TPO antibody levels (>60 IU/mL) and were diagnosed with encephalopathy. Results: Out of 100 subjects, 70 subjects were males and 30 were females. Cognitive impairment was seen in 43/100 subjects. Sleep disturbances, insomnia, ataxia and headache were observed in 19,10,9 as well as 7 out of 100 subjects. Seizures as well as tremors were observed in 5 as well as 4 subjects. Neurological aetiology was seen in 49 (49%) patients. Hyponatremia was present in 27(27%) patients and hypoglycaemia was seen in 14 (14%) patients. Pneumonia was the commonest infection present in 10(10%) patients. Conclusion: It is important to screen each patient with hepatic encephalopathy. Physicians, endocrinologists, and neurophysicians may benefit from earlier diagnosis and treatment with positive clinical outcomes if they are more aware of this clinical entity.