Background: The present study was conducted for evaluating the expression of ER and PR in PMB (Post-menopausal women) patients. Materials & methods: A total of 100 patients were enrolled. Complete demographic and clinical details of all the patients was recorded. Samples were obtained and were subjected to immunohistochemical analysis. ER and PR expression was recorded. Correlation of etiopathogenesis of PMB with ER and PR expression was evaluated. Assessment of results was done using SPSS software. Results: ER expression was positive among glandular component in 94 percent of the patients while it was positive in stromal component of 91 percent of the patients. Correlation of ER expression and PR expression with aetiopathogenesis of PMB yielded non-significant results. Conclusion: PMB is accompanied by enhanced expression of ER and PR receptors. Key words: PMB, ER, PR