Background: The present study was conducted for comparing the safety and efficacy of intravaginal misoprostol and intracervical dinoprostone in induction of labour. Materials & methods: 80 subjects were enrolled in the present study and were broadly divided into two study groups as follows: Group 1: Subjects receiving tablet Misoprostol (25 microgram) vaginally four hourly to a maximum of three doses, and Group 2: Subjects receiving Dinoprostone gel (0.5 mg) intracervically for six hours to a maximum of three doses. After drug insertion in their respective study groups, patients were assessed for signs and symptoms of labor. Outcome was assessed. Results: Mean time of onset of labor among the subjects of Group 1 and Group 2 was 61.6 minutes and 88.4 minutes respectively. Significant results were obtained while comparing the mean time of onset of labor among the two study groups. Oxytocin augmentation was required in 12.5% and 20% of the patients of Group 1 and group 2 respectively. Caesarean delivery was done in 3 patients of the Group 1 and 4 patients of Group 2. NICU admission was done in 3 patients of the Group 1 and 2 patient of the Group 2. Non-significant results were obtained while comparing the incidence of complications among the two study groups. Conclusion: In comparison to intracervical dinoprostone, intravaginal misoprostol is significantly better in induction of labour. Key words: Induction, Intravaginal, Misoprostol, Dinoprostone