Third molar eruption and continuous positional changes after eruption can be related not only with race but also with nature of the diet, the intensity of the use of the masticatory apparatus and possibly due to genetic background. The surgical procedure to extract the wisdom teeth accompanies the post-operative complications like pain, swelling, trismus, bruising, and difficulty in chewing and swallowing. Corticosteroids are employed particularly after surgery to limit the accumulation of inflammatory mediators and reduce fluid transudation and edema. Dexamethasone has a wide variety of uses in the medical field. As a treatment, dexamethasone has been useful in the treatment of acute exacerbations of multiple sclerosis, allergies, cerebral edema, inflammation, and shock. Key words: Dexamethasone, Third molar