Oral verrucous carcinoma is a rare tumor first described by Ackerman. It is a special form of well differentiated Squamous Cell Carcinoma with specific clinical and histological features. The tumor grows slowly and locally, invasive in nature and unlikely to metastasize. It appears as a painless, thick white plaque resembling a cauliflower. In recent years, brachytherapy has been used in management of neoplasms of head and neck region.1 This clinical report illustrates a method of customized mould fabrication for a 64 year old patient diagnosed with verrucous carcinoma of dorsum of tongue undergoing brachytherapy treatment and emphasizes the responsibility of a maxillofacial prosthodontist in designing a non-invasive prosthesis which maintains the radiotherapy catheters in the required predetermined position as per the requirement of the radiologist.