Background: Chronic periodontal disease is a major cause of tooth loss. It increases the risk of systemic diseases and adversely affects the quality of life. Allografts are autogenous bone substitutes used to eliminate the need for a second surgical procedure. Two popular forms of allografts are available namely freeze-dried bone allograft (FDBA) and Demineralized freeze dried bone allograft (DFDBA). Hence; we planned the present study to assess and compare autologous Platelet-rich fibrin (PRF) combined with DFDBA to DFDBA alone in treating patients with periodontal intra-bony defects. Materials & methods: The present study included assessment of 20 patients undergoing periodontal flap surgery. All the patients were randomly divided into two study groups. Group A included subjects in which mucoperiosteal flap elevation was done followed by the placement of DFDBA, whereas Group B included subjects in which mucoperiosteal flap elevation was done followed by the placement of homogeneous mixture of PRF with DFDBA. Site-particular plaque list and sulcus draining list were recorded at pattern and again at 3 months, at 6 months post-operatively. Assessment of clinical and radiographic parameters was also done. All the results were analysed by SPSS software. Results: Mean value of probing pocket depth reduction at baseline time and 3 months’ time among group A and B were 2.6 and 3.2 mm respectively. Statistically significant difference was obtained while comparing the mean probing pocket depth reduction among both the groups at different time intervals. Statistically significant difference was obtained while comparing the mean clinical attachment level gain among both the groups at different time intervals. Conclusion: In treating patients with periodontal intrabony defects, PRF with DFDBA yielded better results in clinical parameters in comparison to DFDBA alone in the treatment of periodontal intrabony defects.
Key words: DFDBA, Intra-bony, Periodontal flap