Background: Orthodontic treatment of malocclusions can often resolve them, or at least prevent their progression. Hence; the present study was conducted for assessing the effect of orthodontic treatment on salivary flow rate and salivary pH. Materials & methods: A total of 20 patients scheduled to undergo fixed orthodontic treatment were enrolled. All subjects were treated with a straight wire technique on both the maxillary and the mandibular arches. Before the beginning of treatment, all patients underwent meticulous professional oral hygiene. Every 3 months during active orthodontic treatment, all subjects underwent professional oral hygiene maintenance; more frequent hygienic check-ups were scheduled in the presence of clinical signs of unhealthy gingival conditions. Salivary flow rate and salivary pH was evaluated. Results: Mean salivary flow rate at baseline, 1 month, 2 months and 6 months was 1.06 mL/min, 1.19 mL/min, 1.29 mL/min and 1.39 mL/min respectively. Mean salivary pH at baseline, 1 month, 2 months and 6 months was 7.26, 6.95, 6.75 and 6.56 respectively. Significant results were obtained while comparing the salivary pH and salivary flow rate at different time intervals. Conclusion: Salivary pH and salivary flow rate are significantly altered in patients undergoing fixed orthodontic treatment. Key words: Orthodontic treatment