BACKGROUND: There are many reasons for dental implant failure one of which is the development of bacteremia around implants. The salivary microflora and periodontal microflora pose a potential risk to the implants. To prevent the onset of infection at the site of implant placement prophylactic antibiotics as well as irrigation of the osteotomy sites with an antibiotic are prescribed to elevate the antibiotic concentration in blood and local environment to reduce the chance of bacterial proliferation and dissemination. MATERIAL AND METHOD: A total of 20 implants were placed in 10 subjects. (Group 1- osteotomy site irrigated with normal saline; Group 2- osteotomy site irrigated with clindamycin). The patients were recalled after 1 month, 2 month and 3 month after placement. RESULTS: It was observed that the mean pain levels, crestal bone loss and clinical peri implant infection in group irrigated with Clindamycin was less than that observed in patients irrigated with normal saline. Key words: Clindamycin