|Evaluation of serum LDH levels in women with preeclampsia and its effect on maternal and perinatal outcome|
|Viraj Nandkishor Godbole, Shrikant Arvind Babar|
Background: Hypertensive disorder of pregnancy occurs in approximately 6-8% of all pregnancies. The most serious consequences for the mother and the baby are the result of preeclampsia and eclampsia. Lactate Dehydrogenase (LDH) is an intracellular enzyme. Recently LDH has been suggested as potential marker to predict severity of preeclampsia. Material and methods: A total of 120 patients were included in this study. These patients were divided into 3 groups of 40 each: Group 1: patients with severity of preeclamsia being mild ; Group 2: patients with severity of preeclamsia being severe ; Group 3: normal pregnancy group. All patients were randomly selected irrespective of their age, based on their reporting into the labour room department. Detailed demographic data of all the patients was collected. Their blood samples were taken. These were sent to laboratory for assessment of serum LDH levels. An auto-analyser was used to measure serum LDH levels. Results: The present study was conducted on 120 patients. It was observed that the mean LDH levels in the normotensive group were 170 IU/L. The mean LDH levels in mild pre-eclampsia and severe pre-eclamsia group were 324.6 and 645.8 respectively. The study obtained significant results when comparing normotensive group versus mild pre-eclampsia group with a P-value of 0.01. These figures were not statistically significant. Other parameters like mean birth weight, mean APGAR at 1 minute and 5 minutes, neonatal complications and mortality all showed a significant co-relation with increase in serum LDH levels of more than 800 IU/L. Conclusion: LDH levels showed significant variations in pre-eclampsia patients and thus screening of all cases of Preeclampsia and Eclampsia with LDH levels should be made mandatory. Key words: Eclampsia, hypertension, gestation, lactate dehydrogenase.
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