Aim: To estimate the value and the significance of Alkaline phosphatase and Lactate dehydrogenase in salivary samples of an individual with oral potentially malignant disorders, oral squamous cell carcinoma cases and control groups and to establish the salivary alkaline phosphatase and salivary lactate dehydrogenase as biomarkers for assessing the malignant potential in order to improve the quality of life of the patients. Methods: 5 ml of unstimulated saliva was collected from the patients by spit method in a calibrated test tube. It was then immediately centrifuged at 2500 rpm for 15 minutes. The resulting supernatant was then separated into 1 ml aliquots and subjected for further biochemical assay analysis using standard kit method. The samples will then be diluted in 1:1 ratio with saline and assayed using standard kit and measured using semi auto analyzer. The salivary LDH & salivary ALP concentrations were expressed in terms of IU/L.  Results: A highly significant association was observed in Alkaline phosphatase group with different conditions (p=0.00) with 122.06 F value. A highly significant association was observed in lactate dehydrogenase group with different conditions (p=0.00) with 17.25 F value. Conclusion: Both Alkaline phosphatase and Lactate dehydrogenase are sensitive markers for the detection of pre cancer and cancer hence helpful in early detection of oral carcinoma. Statistical analysis also proves that ALP levels are consistently higher in oral pre cancer and cancer hence it  could be more reliable marker in detection of oral carcinoma in comparison with S- LDH. The roles of S-LDH have to be further evaluated with larger sample size.
 Key words: Leukoplakia, Oral Squamous Cell Carcinoma, Saliva, Lactate dehydrogenase, Alkaline phosphatase.
 
Received: 5 January  2019                                       Revised: 25 January 2019                              Accepted: 28 January 2019
Corresponding author: Dr. Randhir Kumar, Professor & HOD, Dept of Periodontology, Patna Dental College, Patna, Bihar, India

This article may be cited as: Sharma G, Kumar R. Evaluation and Comparison of Salivary Alkaline Phosphatase and Lactate Dehydrogenase in Patients of Potentially Malignant Disorders and Oral Squamous Cell Carcinoma. Int J Res Health Allied Sci 2019; 5(1):41 -44.