Background: CRP is a pentameric plasma protein with homologs in vertebrates and many invertebrates that participate in the systemic response to inflammation. It is a pattern recognition molecule, that is extremely sensitive and non-specific acute-phase marker for inflammation, produced in response to many forms of injury other than binding to specific molecular configurations that are typically exposed during cell death or found on the surfaces of pathogens. There is strong evidence that CRP is increased in otherwise healthy adults with poor periodontal status. Aim of the study: To assess CRP levels in periodontitis patients. Materials and methods: The present study was conducted in the Department of Periodontics of the Dental institution. For the study, we selected patients with periodontitis referred to the department of periodontology. A total of 90 subjects with generalized periodontitis and 90 control healthy patients were selected. The subjects were categorized based on gingival index, clinical attachment loss indices into 3 equal groups of healthy, plaque-induced gingivitis and chronic periodontitis. For the analysis of saliva CRP level, unstimulated saliva sample was collected using spitting method for each subject. Patients were restricted from eating or drinking for 2 hours before collecting samples. Results: A total of 90 patients were enrolled in each group, Periodontitis group and Control group. The mean age of patients in periodontitis group was 45.69 years and in control group was 43.58 years. Mean CRP level in periodontitis group was 4925.31 pg/mL and in control group was 3285.24 pg/mL. The results were compared and were found to be statistically significant. Conclusion: Within the limitations of the present study, it can be concluded that there is statistically significant association of mean CRP level and periodontitis. The level of CRP increases with the severity of periodontitis.