ABSTRACT: Background: A medically compromised patient (MCP) can be described, as the one who has a distinctive physical or mental feature regarding the people of the same age. In this sort of patients there is a higher risk of interactions between their disease and the implant surgery, implying a higher medical risk. Osseointegrated dental implants represent a highly predictable and widespread therapy for rehabilitation of the incomplete dentition. Aim of the study: To evaluate success rate of dental implants in medically compromised patients. Materials and methods: The present study was conducted in the Department of Oral and maxillofacial surgery of the dental institute. Study group consisted of medically compromised patients whereas control group consisted of normal healthy patients. Patient’s age, gender and ASA status were studied for demographic profile. Clinical information retrieved from the files of the patients was preoperative, intraoperative and postoperative parameters. The periodontal status of all the patients before implant insertion was stable. Results: A total of 100 patients participated in the study. 50 patients belonged to study group and the other 50 patients belonged to control group. The number of failed dental implants in study group was 8 and was 3 in control group. Conclusion: Within the limitations of the present study, it can be concluded that the rate of implant failure was more evident in patients with medical comorbidities. Key words: Dental implants, medically compromised, implant success rate.