Background: Systemically healthy patients, demonstrate 90 and 95 % success rates of dental implants as reported over 10 years of follow-up. The present study was conducted to assess success and failure of dental implants in medically compromised patients. Material & methods: The present study was conducted on 48 medically compromised patients and equal number of healthy subjects. Amount of bone loss around the implant, signs of infection and level of bone around the implant were recorded. Survival rate was assessed. Results: Group I (medically compromised) consisted of 48 patients with 70 dental implants. Group II (healthy subjects) consisted of 48 patients with 72 implants. In group I, 14 patients were diabetic, 6 had hypothyroidism and 10 had cardiovascular disease, 6 had osteoporosis and 12 had hypertension. The difference was statistical significant (P<0.05). Survival rate in group I was 68% and I group II was 92%. The difference was significant (P< 0.05). Conclusion: Authors found that medical compromised state affects the outcome of dental implant treatment. Patients such as diabetes, osteoporosis and hypothyroidism etc. had lower survival rate as compared to healthy subjects. Key words: Dental implants, Diabetes, Hypertension